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史向阳 教授

苏州大学

个人履历

史向阳,1970年8月生,现任化学化工与生物工程学院副院长,生物科学与技术研究所教授,博士生导师,校特聘教授,上海高校特聘教授(东方学者)。2008年回国前,在美国密歇根大学历任博士后研究员、第二级副研究员、研究员和研究助理教授。美国化学会、中国化学会、中国生物材料委员会会员,上海市生物物理学会理事,美国密歇根大学医学和生物科学纳米技术研究所客座研究员,首届葡萄牙马德拉大学“邀请纳米技术主任(Invited Chair in Nanotechnology)。是Current Nanoscience、American Journal of Nanotechnology、Advances in Nano Research, An International Journal、Journal of Modern Textile Science and Engineering等期刊编委,也是Nat. Nanotechnol.、Nat. Commun.和 J. Am. Chem. Soc.等84个国际杂志审稿人。

      史向阳教授的主要研究成果包括在纳米医学与生物技术、纳米科学、材料化学、高分子化学和分析化学等领域内共发表或接受发表了306篇SCI期刊论文,10篇书的章节,和269篇会议论文、摘要或报告,并获授权中国发明专利79项。文章总引用数超过12270次,H-index为51。研究工作发表在Chem. Rev., Prog. Polym. Sci., J. Am. Chem. Soc., Adv. Mater., Nano Lett., Small, Adv. Funct. Mater.和Biomaterials等等专业杂志上。近5年(2013-2015)发表通讯作者SCI论文159篇,以通讯作者发表IF>5的论文68篇;获授权发明专利67项,应用7项;出版专著章节6章。

研究方向

                                           1.生物纳米技术:以各种基于树状大分子或生物相容性高分子修饰或组装的多种纳米颗粒为医学平台,研究各种癌症的早期诊断和治疗。 2.新型纳米材料和纳米复合材料的合成、组装、表面修饰、性能、及其在生物医学中的应用。 3.静电纺纳米纤维在生物医学和环境科学中的应用。                                        

研究成果

  2013年以来发表的代表论著

  Han Wang, Linfeng Zheng, Chen Peng, Mingwu Shen, Xiangyang Shi*, Guixiang Zhang.* Folic acid-modified dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human lung adencarcinoma. Biomaterials 2013,34, 470-480 (impact factor 8.806, citation #106).

  Fuyin Zheng#, Shige Wang#, Shihui Wen, Mingwu Shen,** Meifang Zhu, Xiangyang Shi*. Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Biomaterials 2013, 34, 1402-1412 (impact factor 8.806, citation #107).

  Shihui Wen, Kangan Li, Hongdong Cai, Qian Chen, Yunpeng Huang, Chen Peng, Mingwu Shen, Guixiang Zhang*,and Xiangyang Shi*. Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Dual Mode CT/MR Imaging Applications. Biomaterials 2013, 34, 1570-1580(impact factor 8.806, citation #170).

  Hongdong Cai, Xiao An, Jun Cui, Jingchao Li, Shihui Wen, Kangan Li, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang*, Xiangyang Shi*. Facile Hydrothermal Synthesis and Surface Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical Applications. ACS Appl. Mater. Interfaces2013, 5 (5), 1722–1731 (impact factor 8.097, citation #122).

  Qian Chen, Kangan Li , Shihui Wen, Hui Liu, Chen Peng, Hongdong Cai, Mingwu Shen, Guixiang Zhang**, Xiangyang Shi*. Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles. Biomaterials 2013, 34, 5200-5209(impact factor 8.806, citation #131).

  Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* and Xiangyang Shi*. Polyethyleneimine-Mediated Synthesis of Folic Acid-Targeted Iron Oxide Nanoparticles for in Vivo Tumor MR Imaging. Biomaterials2013, 34, 8382-8392 (impact factor 8.806, citation #134, ESI).

  Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Facile One-Pot Synthesis of Fe3O4@Au Composite Nanoparticles for Dual Mode MR/CT Imaging Applications. ACS Appl. Mater. Interfaces2013, 5(20), 10357-10366 (impact factor 8.097, citation #66).

  Dengmai Hu, Yunpeng Huang, Hui Liu, Hong Wang, Shige Wang, Mingwu Shen, Meifang Zhu, Xiangyang Shi*. TheAssembly of Dendrimer-Stabilized Gold Nanoparticles onto Electrospun Polymer Nanofibers for Catalytic Applications. J. Mater. Chem. A2014, 2, 2323–2332 (Impact factor 9.931, citation #22).

  Jingchao Li, Yao He, Wenjie Sun, Hongdong Cai, Yunqi Pan, Mingwu Shen**, Jindong Xia***, Xiangyang Shi*. Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging. Biomaterials2014, 35, 3666-3677 (impact factor 8.806, citation #126, ESI).

  Shige Wang, Jingyi Zhu, Mingwu Shen, Meifang Zhu, Xiangyang Shi*. Poly(amidoamine) Dendrimer-Enabled Simultaneous Stabilization and Functionalization of Electrospun Poly(γ-glutamic acid) Nanofibers. ACS Appl. Mater. Interfaces2014, 6, 2153−2161 (impact factor 8.097, citation # 14).

  Hui Liu+, Han Wang+, Yanhong Xu, Mingwu Shen, Jinglong Zhao, Guixiang Zhang*, Xiangyang Shi*. Synthesis of PEGylated Low Generation Dendrimer-Entrapped Gold Nanoparticles for CT Imaging Applications. Nanoscale2014, 6(9), 4521-4526 (impact factor 7.233, citation #42).

  Hui Liu, Han Wang, Yanhong Xu, Rui Guo, Shihui Wen, Yunpeng Huang, Weina Liu, Mingwu Shen*, Jinglong Zhao, Guixiang Zhang*, and Xiangyang Shi*. Lactobionic Acid-Modified Dendrimer-Entrapped Gold Nanoparticles for Targeted CT Imaging of Human Hepatocellular Carcinoma. ACS Appl. Mater. Interfaces2014, 6, 6944−6953 (impact factor 8.097, citation # 60).

  Jingyi Zhu, Linfeng Zheng, Shihui Wen, Yueqin Tang, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*. Targeted Cancer Theranostics Using Alpha-Tocopheryl Succinate-Conjugated Multifunctional Dendrimer-Entrapped Gold Nanoparticles. Biomaterials2014, 35, 7635-7646 (impact factor 8.806, citation #80).

  Kai Li, Shige Wang, Shihui Wen, Yueqin Tang, Jipeng Li, Xiangyang Shi,* and Qinghua Zhao*. Enhanced In Vivo Antitumor Efficacy of Doxorubicin Encapsulated within Laponite Nanodisks. ACS Appl. Mater. Interfaces2014, 6, 12328−12334 (impact factor 8.097, citation # 22).

  Fanfan Fu, Jingyi Zhu, Shihui Wen, Mingwu Shen, Xiangyang Shi*. Multifunctional lactobionic acid-modified dendrimers for targeted drug delivery to liver cancer cells: Investigating the role played by PEG spacer. ACS Appl. Mater. Interfaces2014, 6, 16416−16425 (impact factor 8.097, citation # 55).

  Benqing Zhou, Linfeng Zheng, Chen Peng, Du Li, Jingchao Li, Shihui Wen, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Synthesis and characterization of PEGylated polyethyleneimine-entrapped gold nanoparticles for blood pool and tumor CT imaging. ACS Appl. Mater. Interfaces2014, 6, 17190−17199 (impact factor 8.097, citation #57).

  Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen*, Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials 2015, 38, 10-21 (impact factor 8.806, citation #136, ESI).

  Lingdan Kong, Carla S. Alves, Wenxiu Hou, Jieru Qiu, Helmuth Möhwald, Helena Tomás,* Xiangyang Shi*. RGD Peptide-Modified Dendrimer-Entrapped Gold Nanoparticles Enable Highly Efficient and Specific Gene Delivery to Stem Cells. ACS Appl. Mater. Interfaces2015, 7 (8), 4833-4843 (impact factor 8.097, citation #49, ESI).

  Jia Yang, Yu Luo, Yanhong Xu, Jingchao Li, Zaixian Zhang, Han Wang, Mingwu Shen, Xiangyang Shi,* Guixiang Zhang*. Conjugation of iron oxide nanoparticles with RGD-modified dendrimers for targeted tumor MR imaging. ACS Appl. Mater. Interfaces2015, 7(9), 5420-5428 (impact factor 8.097, citation #20).

  Yu Luo, He Shen, Yongxiang Fang, Yuhua Cao, Jie Huang, Mengxin Zhang, Jianwu Dai,* Xiangyang Shi,* and Zhijun Zhang*. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl. Mater. Interfaces2015, 7 (11), 6331–6339 (impact factor 8.097, citation #92).

  Zheng Qiao, Xiangyang Shi*. Dendrimer-based molecular imaging contrast agents. Prog. Polym. Sci. 2015, 44, 1–27 (Impact factor 24.558, citation #50).

  Yu Luo, Jia Yang, Yu Yan, Jingchao Li, Mingwu Shen*, Guixiang Zhang,* Serge Mignani, Xiangyang Shi*. RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of glioma. Nanoscale2015, 7, 14538–14546 (impact factor 7.233, citation #31).

  Hongdong Cai#, Kangan Li#, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors. Small2015, 11 (35), 4584-4593 (impact factor 9.598, citation #56).

  Yulin Li*, Dina Maciel, João Rodrigues*, Xiangyang Shi*, Helena Tomás*. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chem. Rev.2015,115 (16), 8564–8608 (impact factor 52.613, citation #108).

  Lingzhou Zhao, Jingyi Zhu, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Lilei Guo, Xiangyang Shi*, and Jinhua Zhao*. Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide 131I for SPECT Imaging and Radiotherapy of Gliomas. ACS Appl. Mater. Interfaces2015, 7 (35), 19798–19808 (impact factor 8.097, citation #17).

  Jingyi Zhu, Lingzhou Zhao, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Mingwu Shen, Jinhua Zhao,* and Xiangyang Shi*. Radionuclide 131I-Labeled Multifunctional Dendrimers for Targeted SPECT Imaging and Radiotherapy of Tumors. Nanoscale2015, 7, 18169-18178 (impact factor 7.233, citation #13).

  Yongxing Zhang#, Shihui Wen#, Lingzhou Zhao#, Du Li#, Changcun Liu, Wenbin Jiang, Xiang Gao, Wentao Gu, Nan Ma, Jinhua Zhao*, Xiangyang Shi*, Qinghua Zhao*. Ultrastable polyethyleneimine-stabilized gold nanoparticles modified with polyethylene glycol for blood pool, lymph node and tumor CT imaging. Nanoscale2016, 8, 5567–5577 (impact factor 7.233, citation #15).

  Jingwen Chen#, Yingqi Sun#, Qian Chen#, Le Wang, Suhe Wang, Yun Tang,* Xiangyang Shi*, Han Wang*. Multifunctional gold nanocomposites designed for targeted CT/MR/optical tri-modal imaging of human non-small cell lung cancer cells. Nanoscale2016, 8, 13568–13573 (impact factor 7.233, citation #8).

  Xin Li#, Zuogang Xiong#, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and Xiangyang Shi*. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors. ACS Appl. Mater. Interfaces2016, 8, 19883-19891(impact factor 8.097, citation #18).

  Aijun Li, Benqing Zhou, Carla S. Alves, Bei Xu, Rui Guo, Xiangyang Shi,* Xueyan Cao*. Mechanistic Studies of the Enhanced PCR Using PEGylated PEI-Entrapped Gold Nanoparticles. ACS Appl. Mater. Interfaces2016, 8 (39), 25808–25817 (impact factor 8.097, citation #6).

  Peng Wang#, Jia Yang#, Benqing Zhou, Yong Hu, Lingxi Xing, Fanli Xu, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*. Antifouling manganese oxide nanoparticles: Synthesis, characterization, and applications for enhanced MR imaging of tumors. ACS Appl. Mater. Interfaces 2017, 9 (1), 47–53 (impact factor 8.097, citation #8).

  Wenjie Sun#, Sabrina Thies#, Jiulong Zhang, Chen Peng*, Guangyu Tang, Mingwu Shen, Andrij Pich*, Xiangyang Shi*. Gadolinium-Loaded Poly(N-vinylcaprolactam) Nanogels: Synthesis, Characterization, and Application for Enhanced Tumor MR Imaging. ACS Appl. Mater. Interfaces 2017, 9 (4), 3411-3418 (impact factor 8.097, citation #13).

  Xin Li#, Lingxi Xing#, Kailiang Zheng, Ping Wei, Lingzhou Zhao, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. Formation of Gold Nanostar-Coated Hollow Mesoporous Silica for Tumor Multi-Modality Imaging and Photothermal Therapy. ACS Appl. Mater. Interfaces 2017, 9, 5817−5827 (impact factor 8.097, citation #27).

  Lingdan Kong#, Lingxi Xing#, Benqing Zhou, Lianfang Du*, Xiangyang Shi*. Dendrimer-Modified MoS2 Nanoflakes as a Platform for Combinational Gene Silencing and Photothermal Therapy of Tumors. ACS Appl. Mater. Interfaces 2017, 9 (19), 15995–16005 (impact factor 8.097, citation #11).

  Nuo Yu#, Yong Hu#, Gang Liu, Xiaoyong Wang, Zhaojie Wang, Zixiao Liu, Meifang Zhu, Xiangyang Shi*, Zhigang Chen*. Dynamically Tuning Near-infrared-induced Photothermal Performances of TiO2 Nanocrystals by Nb-doping for Imaging Guided Photothermal Therapy of Tumors. Nanoscale2017, 9, 9148–9159 (impact factor 7.233, citation #8).

  Zhijuan Xiong#, Yue Wang#, Jingyi Zhu, Xin Li, Yao He, Jiao Qu, Mingwu Shen, Jindong Xia,* and Xiangyang Shi*. Dendrimers meet zwitterions: Development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging. Nanoscale2017, 9, 12295-12301 (impact factor 7.233, citation #5).

  Yiwei Zhou, Yong Hu, Wenjie Sun, Benqing Zhou, Jianzhi Zhu, Chen Peng*, Mingwu Shen, Xiangyang Shi*. Polyaniline-Loaded γ-Polyglutamic Acid Nanogels as a Platform for Photoacoustic Imaging-Guided Tumor Photothermal Therapy. Nanoscale2017, 9, 12746-12754 (impact factor 7.233, citation #3).

  Jingchao Li, Shige Wang, Xiangyang Shi,* Mingwu Shen*. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci. 2017, 249, 374–385 (impact factor 7.346, citation #2).

  Lizhou Lin#, Yu Fan#, Feng Gao, Lifang Jin, Dan Li, Wenjie Sun,Fan Li, Peng Qin, Qiusheng Shi*, Xiangyang Shi*, Lianfang Du*.UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy. Theranostics2018, 8(7), 1923-1939 (impact factor 8.537, citation #8).

  Serge Mignani*, João Rodrigues*, Helena Tomas, Maria Zablocka, Xiangyang Shi, Anne-Marie Caminade, Jean-Pierre Majoral*. Dendrimers in combination with natural products and analogues as anti-cancer agents. Chem. Soc. Rev.2018, 47, 514-532 (citation # 15, Impact factor 40.182).

  Benqing Zhou#, Ruizhi Wang#, Lingzhou Zhao, Peng Wang, Xin Li, Istva?n Ba?nyai,* Qiang Ouyang*, Xiangyang Shi, and Mingwu Shen*. 99mTc-Labeled RGD−Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma. ACS Appl. Mater. Interfaces 2018, 10 (7), 6146–6154 (impact factor 8.097, citation #4).

  Jean-Pierre Majoral*,Maria Zablocka*, Anne-Marie Caminade, Piotr Balczewski,Xiangyang Shi, Serge Mignani*. Interactions gold/phosphorus dendrimers. Versatile ways to hybrid organic-metallic macromolecules.Coord. Chem. Rev.2018, 358, 80-91 (impact factor 14.499, citation # 3).

  Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*.Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev.2018, 47, 1874-1900 (citation # 33, Impact factor 40.182).

  Zheng Qiao, Mingwu Shen, Yunchao Xiao, Meifang Zhu, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*. Organic/inorganic nanohybrids formed using electrospun polymer nanofibers as nanoreactors.Coord. Chem. Rev.2018, 372, 31-51 (impact factor 14.499, citation # 2).

  Jingyi Zhu#, Hongsheng Li#, Zhijuan Xiong, Mingwu Shen, Peter S. Conti, Xiangyang Shi*, Kai Chen*. Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET/MR imaging. ACS Appl. Mater. Interfaces 2018, 10(41), 34954-34964 (impact factor 8.097, citation #0).

  Serge Mignani*, João Rodrigues, Helena Tomas, René Roy, Xiangyang Shi, Jean-Pierre Majoral*. Bench-to-bedside translation of dendrimers: Reality or utopia? A concise analysis. Adv. Drug Deliver. Rev.2018, 136–137, 73–81 (impact factor 13.66, citation # 2).

  Shiyi Lu, Xin Li, Jiulong Zhang, Chen Peng,* Mingwu Shen,* and Xiangyang Shi*. Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors. Adv. Sci.2018, 5, 1801612 (citation # 0, Impact factor 12.441).

  Wenhui Ma#, Fanfan Fu#, Jingyi Zhu, Rui Huang, Yizhou Zhu, Zhenwei Liu, Jing Wang, Peter S. Conti, Xiangyang Shi*, Kai Chen*. 64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging. Nanoscale2018, 10, 6113–6124 (impact factor 7.233, citation #3).

  Yu Fan, Jiulong Zhang, Menghan Shi, Dan Li, Chunhua Lu, Xueyan Cao, Chen Peng*, Serge Mignani*, Jean-Pierre Majoral*, Xiangyang Shi*. PAMAM Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for Radiotherapy-Enhanced MR Imaging and Chemotherapy of Tumors and Tumor Metastasis. Nano Lett.2019, 19, 1216−1226(citation # 0, Impact factor 12.08).

  Xinxin Hao, Bei Xu, Huan Chen, Xiaomeng Wang, Jiulong Zhang, Rui Guo, Xiangyang Shi* and Xueyan Cao*. Stem Cells-Mediated Delivery of Nanogels Loaded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Tumor MR Imaging. Nanoscale2019, in press (impact factor 7.233, citation #0).

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1
采用电纺丝法制备了前驱体纳米纤维膜,固化的纳米纤维均匀分布。在随后的热解过程中,PVP被碳化成相互连接的3D碳骨架,纳米纤维形态得到了很好的保存。

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