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史向阳 教授

苏州大学

个人履历

史向阳,1970年8月生,化学化工与生物工程学院,生物科学与技术研究所教授,博士生导师,校特聘教授,上海高校特聘教授(东方学者)。2008年回国前,在美国密歇根大学历任博士后研究员、第II级副研究员、研究员和研究助理教授。美国化学会、Sigma Xi 学会、中国化学会、中国生物材料委员会会员,是美国密歇根大学医学和生物科学纳米技术研究所客座研究员,首届葡萄牙马德拉大学“邀请纳米技术主任(Invited Chair in Nanotechnology)。是Nat. Nanotechnol.和 J. Am. Chem. Soc.等64个国际杂志审稿人。主要从事纳米医学、环境纳米技术、纳米化学和纳米材料合成及其应用研究。已申请发明专利21项,参加编写6篇书的章节,发表论文120多篇(SCI检索90多篇)。

教育:

 1988/9-1992/7       理学学士      河南师范大学         化学

1992/9-1995/4       工学硕士      北京理工大学         应用化学

1995/9-1998/7       理学博士      中科院感光化学研究所        有机化学

工作经历:

1998/9-2000/5          博士后          清华大学

2000/5-2001/5         博士后          德国马克斯-普朗克胶体与界面研究所

2001/5-2002/5        访问学者       美国加州州立大学洛杉矶分校

2002/5-2003/5        博士后           美国密歇根大学安娜堡分校

2003/5-2005/5        第II级副研究员          美国密歇根大学安娜堡分校

2005/6-2008/4        研究员           美国密歇根大学安娜堡分校

2008/5-2008/8        研究助理教授          美国密歇根大学安娜堡分校

2008/6-至今            校特聘教授          东华大学

2008/6-至今           上海高校特聘教授(东方学者)          东华大学

2010/11-至今         邀请纳米技术主任          葡萄牙马德拉大学 (兼职)


研究方向

1.生物纳米技术:以各种基于树状大分子或生物相容性高分子修饰或组装的多种纳米颗粒为医学平台,研究各种癌症的早期诊断和治疗。  

2.新型纳米材料和纳米复合材料的合成、组装、表面修饰、性能、及其在生物医学中的应用。 3.静电纺纳米纤维在生物医学和环境科学中的应用。          

                              

研究成果

学术兼职:

1.      美国化学会、Sigma Xi 学会会员,中国化学会、中国生物材料委员会会员;

2.      美国密歇根大学医学和生物科学纳米技术研究所客座研究员;

3.      葡萄牙马德拉大学化学系邀请纳米技术主任(Invited Chair in Nanotechnology);

4.      Journal of Modern Textile Science and Engineering, 中国组织工程研究与临床康复编委;

5.      Nature Nanotechnology, Journal of the American Chemical Society, Nano Letters, Chemical Communications, Biomacromolecules, Journal of Materials Chemistry, Lab on a Chip, Journal of Physical Chemistry B, Molecular Biosystems, Green Chemistry, Langmuir, Analyst, Nanotechnology, Dalton Transactions, Soft Matter, Physical Chemistry Chemical Physics, Bioorganic & Medicinal Chemistry, CrystEngComm, European Journal of Inorganic Chemistry, Colloids and Surfaces A: Physicochemical Engineering Aspects, Journal of Optics A: Pure and Applied Optics, Polymer Bulletin, Journal of Physics: Condensed Matter, Molecules, Journal of Nanoscience and Nanotechnology, Acta Biomaterialia,Journal of Environmental Monitoring,Organic & Biomolecular Chemistry, Journal of Physics D: Applied Physics,IEEE Engineering in Medicine and Biology Magazine,New Journal of Chemistry, Nanotechnology, Science and Applications 等56个国际专业杂志的审稿人;

6.      国家自然科学基金、教育部博士点基金和霍英东青年教师基金评审人,新加坡国立大学校基金项目评审人,美国Cottrell College Science Award proposal from Research Corporation for Science Advancement基金评审人,加拿大Alberta Nanotechnology Industrial Research Partnership Program 评审人,上海市科委重点项目评审人;

7.       2006年14届复合物和纳米工程国际会议生物复合材料分会主席,2009年BIT Life Sciences’ 2nd Annual Congress and Expo of Molecular Diagnostics (CEMD-2009) 分会主席,2010年6th IUPAC International Symposium on Novel Materials and Their Synthesis (NMS-VI) and 20th International Symposium on Fine Chemistry and Functional Polymers (FCFP-XX)分会主席。

 

代表性著作:

1.      Wen Jin, Xiangyang Shi, Frank Caruso. High Activity Enzyme Microcrystal Multilayer Films.J. Am. Chem. Soc. 2001,123, 8121-8122.

2.      Frank Caruso,Xiangyang Shi, Rachel A. Caruso, Andrei Susha. Hollow Titania Spheres from Layered Precursor Deposition on Sacrificial Colloidal Core Particles. Advanced Materials 2001, 13, 740-744.

3.      Xiangyang Shi,* Wanyun Ma, Caomin Sun, Shikang Wu. The aggregation behavior of collagen in aqueous solution and its property of stabilizing liposomes in vitro. Biomaterials 2001, 22 (12): 1627-1634.

4.      Xiangyang Shi, Shubo Han, Raymond J. Sanedrin, Cesar Galvez, David G. Ho, Billy Hernandez, Feimeng Zhou, Matthias Selke. Formation of Cobalt Oxide Nanotubes: Effect of Intermolecular Hydrogen Bonding Between Co(III) Complex Precursors Incorporated onto Colloidal Templates. Nano Lett. 2002, 2, 289-293.

5.      Xiangyang Shi, Shubo Han, Raymond J. Sanedrin, Feimeng Zhou, Matthias Selke. Synthesis of Cobalt Oxide Nanotubes from Colloidal Particles Modified with a Co(III)-Cysteinato Precursor. Chem. Mater. 2002, 14, 1897-1902.

6.      Shubo Han, Xiangyang Shi, Feimeng Zhou. Polyelectrolyte Hollow Sphere Lithographic Patterning of Surfaces: Construction of 2-Dimensional Well-Ordered Metal Arrays. Nano Lett. 2002, 2, 97-100.

7.      Xiangyang Shi,* Mingwu Shen, Helmuth Moehwald. Polyelectrolyte multilayer nanoreactors toward the synthesis of diverse nanostructured materials. Invited review. Prog. Polym. Sci. 2004, 29, 987-1019.

8.      Mohammad T. Islam, Xiangyang Shi, Lajos P. Balogh, James R. Baker jr. HPLC separation of different generations of poly(amidoamine) (PAMAM) dendrimers modified with various terminal groups. Anal. Chem. 2005, 77, 2063-2070

9.      Xiangyang Shi, Istvan J. Majoros, James R. Baker Jr. Capillary Electrophoresis of Poly(amidoamine) Dendrimers: From Simple Derivatives to Complex Multi-functional Medical Nanodevices.Invited review. Mol. Pharmaceutics 2005, 2, 278-294.

10.   Wojciech Lesniak, Anna Bielinska, Kai Sun, Katarzyna Janczak, Xiangyang Shi, James R. Baker, Jr., Lajos Balogh. Silver/Dendrimer Nanocomposites as Biomarkers: Fabrication,Characterization, In Vitro Toxicity and Intracellular Detection. Nano Lett. 2005, 5, 2123-2130.

11.   Xiangyang Shi, István J. Majoros, Anil K. Patri, Xiangdong Bi, Mohammad T. Islam, Ankur Desai, T. Rose Ganser, James R. Baker, Jr. Molecular heterogeneity analysis of poly(amidoamine) dendrimer-based mono- and multifunctional nanodevices by capillary electrophoresis. Analyst 2006, 131, 374-381.

12.   Xiangyang Shi, Suhe Wang, Xisui Chen, Sasha Meshinchi, James R. Baker Jr. Encapsulation of Submicrometer-Sized 2-Methoxyestradiol Crystals into Polymer Multilayer Capsules for Biological Applications. Mol. Pharmaceutics 2006, 3, 144-151.

13.   Xiangyang Shi, Kai Sun, Lajos Balogh, James R. Baker, Jr. Synthesis, Characterization, and Manipulation of Dendrimer-Stabilized Iron Sulfide Nanoparticles. Nanotechnology 2006, 17, 4554-4560

14.   Xiangyang Shi,* Suhe Wang, Haiping Sun, James R. Baker Jr.* Improved Biocompatibility of Dendrimer-Entrapped Gold Nanoparticles. Soft Matter 2007, 3, 71-74

15.   Xiangyang Shi,* Suhe Wang,*Sasha Meshinchi,Mary E. Van Antwerp,Xiangdong Bi, Inhan Lee,James R. Baker, Jr*.Dendrimer-Entrapped Gold Nanoparticles as a Nanoplatform for Cancer-Cell Targeting and Imaging. Small 2007, 3, 1245-1252.

16.   Su He Wang*, Xiangyang Shi*, Mary Van Antwerp, Zhengyi Cao,Scott D. Swanson, Xiangdong Bi, James R. Baker, Jr.* Dendrimer-Functionalized Iron Oxide Nanoparticles for Specific Targeting and Imaging of Cancer Cells. Adv. Funct. Mater.2007, 17, 3403-3050.

17.   Xiangyang Shi*, Inhan Lee, James R. Baker, Jr*. Acetylation of dendrimer-entrapped gold and silver nanoparticles. J. Mater. Chem. 2008, 18, 586-593.

18.   Xiangyang Shi*, Su He Wang*, Scott D. Swanson,Song Ge, Zhengyi Cao, Mary Van Antwerp, Kevin J Landmark, James R. Baker, Jr*. Dendrimer-functionalized shell-crosslinked iron oxide nanoparticles for in vivo magnetic resonance imaging of tumors. Adv. Mater., 2008, 20, 1671-1678.

19.   Xiangyang Shi, Kai Sun, and James R. Baker, Jr. Spontaneous Formation of Functionalized Dendrimer-Stabilized Gold Nanoparticles. J. Phys. Chem. C. 2008, 112, 8251-8258.

20.   Mingwu Shen, Su He Wang, Xiangyang Shi, Xisui Chen, Qingguo Huang, Elijah J. Petersen, Roger A. Pinto, James R. Baker, Jr., and Walter J. Weber, Jr. Polyethyleneimine-Mediated Functionalization of Multi-Walled Carbon Nanotubes: Synthesis, Characterization, and in vitro Toxicity Assay. J. Phys. Chem. C 2009, 113(8), 3150-3156.

21.   Xiangyang Shi*, Su He Wang, Mingwu Shen, Mary E. Antwerp, Xisui Chen, Chang Li, Elijah J. Petersen, Qingguo Huang, Walter J. Weber, Jr., and James R. Baker, Jr. Multifunctional Dendrimer-Modified Multi-Walled Carbon Nanotubes: Synthesis, Characterization, and in vitro Cancer Cell Targeting and Imaging. Biomacromolecules 2009, 10, 1744-1750.

22.   Seungpyo Hong, Rahul Rattan, István J. Majoros, Douglas G. Mullen, Jennifer L. Peters, Xiangyang Shi, Ania Bielinska, Luz Blanco, Bradford G. Orr, James R. Baker, Jr., and Mark M. Banaszak Holl*. Exploring Membrane Porosity and Cellular Internalization Mechanisms of Poly(amidoamine) Dendrimers:  the Role of Sphingolipid GM1. Bioconjugate Chem. 2009, 20(8), 1503-1513

23.   Shili Xiao, Mingwu Shen, Rui Guo, Shanyuan Wang, and Xiangyang Shi*. Immobilization of Zero-Valent Iron Nanoparticles into Electrospun Polymer Nanofibers: Synthesis, Characterization, and Potential Environmental Applications. J. Phys. Chem. C 2009, 113, 18062-18068

24.   Rui Guo, Han Wang, Chen Peng, Mingwu Shen, Minjie Pan, Xueyan Cao, Guixiang Zhang*, Xiangyang Shi*. X-Ray Attenuation Property of Dendrimer-Entrapped Gold Nanoparticles. J.Phys. Chem. C 2010, 114(1), 50-56

25.   Hong Yang, Cuixia Zhang,Xiangyang Shi,* He Hu,  Xiaoxia Du, Yong Fang, Yanbin Ma,*Huixia Wu, Shiping Yang*. Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging. Biomaterials 2010, 31, 3667-3673

26.   Hong Yang, Yeming Zhuang, He Hu, Xiaoxia Du, Cuixia Zhang, Xiangyang Shi,*Huixia Wu, and Shiping Yang*. Silica-Coated Manganese Oxide Nanoparticles as a Platform for Targeted Magnetic Resonance and Fluorescence Imaging of Cancer Cells.Adv. Funct. Mater. 2010, 20, 1733-1741

27.   Xiangyang Shi*, Inhan Lee, Xisui Chen, Mingwu Shen, Shili Xiao, Meifang Zhu, and James R. Baker, Jr., Su He Wang*. Influence of dendrimer surface charge on the bioactivity of 2-methoxyestradiol complexed with dendrimers.Soft Matter 2010, 6, 2539-2545

28.   Shili Xiao, Mingwu Shen, Rui Guo, Qingguo Huang, Shanyuan Wang, Xiangyang Shi*. Fabrication of Multiwalled Carbon Nanotube-Reinforced Electrospun Polymer Nanofibers Containing Zero-Valent Iron Nanoparticles for Environmental Applications. J. Mater. Chem. 2010, 20, 5700-5708

29.   Mingwu Shen and Xiangyang Shi*. Dendrimer-based organic/inorganic hybrid nanoparticles in biomedical applications. Nanoscale 2010, 2, 1596-1610

30.   Ruiling Qi, Rui Guo, Mingwu Shen, Xueyan Cao, Leqiang Zhang, Jiajia Xu, Jianyong Yu, Xiangyang Shi*. Electrospun Poly(lactic-co-glycolic acid)/Halloysite Nanotube Composite Nanofibers for Drug Encapsulation and Sustained Release. J. Mater. Chem. 2010, 20, 10622-10629

31.   Han Wang, Linfeng Zheng, Chen Peng, Rui Guo, Mingwu Shen, Xiangyang Shi*, Guixiang Zhang*. Computed Tomography Imaging Of Cancer Cells Using Acetylated Dendrimer-Entrapped Gold Nanoparticles. Biomaterials 2011, 32, 2979-2988

32.   Yin Wang, Rui Guo, Xueyan Cao, Mingwu Shen, and Xiangyang Shi Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy. Biomaterials 2011, 32, 3322-3329

33.   Xu Fang,Hui Ma, Shili Xiao,Mingwu Shen,Rui Guo,Xueyan Cao,and Xiangyang Shi*.Facile Immobilization of Gold Nanoparticles into Electrospun Polyethyleneimine/Polyvinyl Alcohol Nanofibers for Catalytic Applications. J. Mater. Chem. 2011, 21 (12), 4493-4501

34.   Rui Guo, Han Wang, Chen Peng, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*.Enhanced X-Ray Attenuation Property of Dendrimer-Entrapped Gold Nanoparticles Complexed with Diatrizoic Acid. J. Mater. Chem. 2011, 21 (13), 5120-5127

35.   Xueyan Cao, Jingjing Chen, Shihui Wen, Chen Peng, Mingwu Shen, and Xiangyang Shi*. Effect of Surface Charge of Polyethyleneimine-Modified Multiwalled Carbon Nanotubes on the Improvement of Polymerase Chain Reaction. Nanoscale 2011, 3 (4), 1741-1747.

36.   Hong Yang, Yeming Zhuang, Yun Sun, Antao Dai, Xiangyang Shi,* Dongmei Wu, Fuyou Li, He Hu and Shiping Yang*. Targeted Dual Contrast T1- and T2-weighted Magnetic Resonance Imaging of Tumors using Multifunctional Gadolinium-Labeled Superparamagnetic Iron Oxide Nanoparticles. Biomaterials 2011,32, 4584-4593

37.   Yulin Li*, Dina Maciel, Helena Tomás, João Rodrigues, Hui Ma, Xiangyang Shi. pH Sensitive laponite/alginate hybrid hydrogels: swelling behavior and release mechanism. Soft Matter 2011, 7(13), 6231-6238

 国际交流与合作:

美国密歇根大学(University of Michigan, Ann Arbor),美国加州州立大学(California State University, Los Angeles), 美国乔治亚大学格里芬分校(University of Georgia, Griffin), 美国麻省大学艾姆赫斯特分校(University of Massachusetts Amherst),德国马普胶体与界面研究所(Max-Planck Institute of Colloids and Interfaces), 葡萄牙马德拉大学 (Universidade da Madeira), 匈牙利徳布勒森大学(University of Debrecen)。

 


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1
采用电纺丝法制备了前驱体纳米纤维膜,固化的纳米纤维均匀分布。在随后的热解过程中,PVP被碳化成相互连接的3D碳骨架,纳米纤维形态得到了很好的保存。

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